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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Guangtao Zhang
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Guangtao Zhang:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Taschenbuch

2011, ISBN: 3639309693

[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Mehr…

NEW BOOK. Versandkosten: EUR 10.99 AHA-BUCH GmbH, Einbeck, Germany [51283250] [Note: 5 (sur 5)]
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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:

Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

ISBN: 9783639309690

*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Mehr…

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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

ISBN: 3639309693

Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulat… Mehr…

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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - Taschenbuch

ISBN: 9783639309690

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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

2011, ISBN: 9783639309690

Trade paperback, New., Trade paperback (US). Glued binding. 160 p., [PU: VDM Verlag]

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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Detailangaben zum Buch - Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR


EAN (ISBN-13): 9783639309690
ISBN (ISBN-10): 3639309693
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2011
Herausgeber: VDM Verlag Dr. Müller

Buch in der Datenbank seit 2009-07-01T15:06:36+02:00 (Berlin)
Detailseite zuletzt geändert am 2023-06-25T11:07:36+02:00 (Berlin)
ISBN/EAN: 3639309693

ISBN - alternative Schreibweisen:
3-639-30969-3, 978-3-639-30969-0
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: zhang
Titel des Buches: synthesis, helix


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