ISBN: 9780128041987

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. M… Mehr…

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders.The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models.The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder Academic Press Orthopedics 1?-hydroxylase deficiency; 24-hydroxylase deficiency; 25-hydroxylase deficiency; 25-hydroxyvitamin D; GNAS mutation; SQSTM1; acrodysostosis; ACVR1; Albright osteodystrophy; ALK2; alopecia; animal model; animal models; apoptosis; arterial calcification due to deficiency of CD73; arthritis; articular cartilage; association; associational studies; autophagy; autosomal dominant hypocalcemia; Bartter's syndrome; biomechanics; birth defects; bisphosphonates; BMD; BMP; bone; bone biology; bone formation; bone geometry; bone loss; bone marrow microenvironment; bone marrow stromal cell; bone metabolism; bone microarchitecture; bone mineral density; bone morphogenetic proteins; bone repair; bone resorption; bone strength; brittle bone disease; calcification; calcitonin; calcitonin receptor; calcitriol; calcium; calcium to creatinine clearance ratio; calcium-sensing receptor; cAMP signaling pathway; cancer; candidate genes; cartilage; cartilage repair; cell fate; central nervous system; chondrocalcinosis; chondrocyte; chondrodysplasias; chromatin; claudins; CNV; collagen helix overmodification; colony-forming unit-fibroblast; copy number variation; counseling; CRISPR/Cas9; deiodinase; disease; Dmp1; DNA methylation; DNase hypersensitivity sites; ectopic calcification; endochondral bone development; endochondral ossification; endocrine glands; endocrine organ; enzyme; enzymopathy; epigenetic therapy; epigenetics; estradiol; estrogen receptor; ethical; extracellular matrix; extrinsic effects; familial expansile osteolysis; familial hypocalciuric hypercalcemia; familial tumoral calcinosis; fetus; FGF-23; fibroblast growth factor-23 (FGF23); fibrodysplasia ossificans progressiva; fibrous dysplasia; FOP; fracture; fracture healing; fracture risk; Gs mutations; gene therapy 9780128041826 DE,GB,ES,IT,FR English Medicine, Elsevier Science<

ISBN: 9780128041987

Academic Press Orthopedics 1?-hydroxylase deficiency; 24-hydroxylase deficiency; 25-hydroxylase deficiency; 25-hydroxyvitamin D; GNAS mutation; SQSTM1; acrodysostosis; ACVR1; Albright ost… Mehr…

Academic Press Orthopedics 1?-hydroxylase deficiency; 24-hydroxylase deficiency; 25-hydroxylase deficiency; 25-hydroxyvitamin D; GNAS mutation; SQSTM1; acrodysostosis; ACVR1; Albright osteodystrophy; ALK2; alopecia; animal model; animal models; apoptosis; arterial calcification due to deficiency of CD73; arthritis; articular cartilage; association; associational studies; autophagy; autosomal dominant hypocalcemia; Bartter's syndrome; biomechanics; birth defects; bisphosphonates; BMD; BMP; bone; bone biology; bone formation; bone geometry; bone loss; bone marrow microenvironment; bone marrow stromal cell; bone metabolism; bone microarchitecture; bone mineral density; bone morphogenetic proteins; bone repair; bone resorption; bone strength; brittle bone disease; calcification; calcitonin; calcitonin receptor; calcitriol; calcium; calcium to creatinine clearance ratio; calcium-sensing receptor; cAMP signaling pathway; cancer; candidate genes; cartilage; cartilage repair; cell fate; central nervous system; chondrocalcinosis; chondrocyte; chondrodysplasias; chromatin; claudins; CNV; collagen helix overmodification; colony-forming unit-fibroblast; copy number variation; counseling; CRISPR/Cas9; deiodinase; disease; Dmp1; DNA methylation; DNase hypersensitivity sites; ectopic calcification; endochondral bone development; endochondral ossification; endocrine glands; endocrine organ; enzyme; enzymopathy; epigenetic therapy; epigenetics; estradiol; estrogen receptor; ethical; extracellular matrix; extrinsic effects; familial expansile osteolysis; familial hypocalciuric hypercalcemia; familial tumoral calcinosis; fetus; FGF-23; fibroblast growth factor-23 (FGF23); fibrodysplasia ossificans progressiva; fibrous dysplasia; FOP; fracture; fracture healing; fracture risk; Gs mutations; gene therapy , UK,GB,DE,ES,FR,IT,US,CA,MX,AU,NZ 20171031 English Medicine 2, Elsevier Science<

ISBN: 9780128041987

This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of t… Mehr…

This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease. Digital Content>E-books>Medicine>Medical Ref>Spec Procedure, Elsevier Science Digital >16<

ISBN: 9780128041987

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. M… Mehr…

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehens Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehens, Academic Press<

2017, ISBN: 9780128041987

eBooks, eBook Download (EPUB,PDF), Auflage, [PU: Elsevier Science], [ED: 2], Elsevier Science, 2017