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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases - Matthew Jenner
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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases - neues Buch

4, ISBN: 9783319327235

ID: 203179783319327235

This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. In addition, the ability to alter the substrate tolerance of K This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. In addition, the ability to alter the substrate tolerance of KS domains by simple point mutations in the active site has been demonstrated. A series of acyl-ACPs have been synthesised using a novel methodology and employed to probe the substrate specificity of both KS domains and the previously uncharcterised acyl hydrolase domain, PedC. KS-catalysed chain elongation reactions have also been conducted and monitored by ESI-MS/MS. All KS domains studied exhibited higher substrate specificity at the elongation step than in the preceeding acylation step. Furthermore, a mechanism of reversible acylation is proposed using the PsyA ACP1-KS1 di-domain. The findings in this thesis provide important insights into mechanisms of KS specificity and show that mutagenesis can be used to expand the repertoire of acceptable substrates for future PKS engineering. Spectrum Analysis, Physics, Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases~~ Matthew Jenner~~Spectrum Analysis~~Physics~~9783319327235, en, Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases, Matthew Jenner, 9783319327235, Springer, 04/27/2016, , , , Springer, 04/27/2016

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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases - Jenner Matthew
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Jenner Matthew:

Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases - neues Buch

ISBN: 9783319327235

ID: 9783319327235

This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases: This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. Acyl Hydrolase Biosynthesis, Enzymes Enzymatic Domains Ketosynthase Mass Spectrometry Polyketide Synthases B Mass Spectrometry Biochemical Engineering Medical Biochemistry Enzymology Chemistry and Materials Science, Springer International Publishing

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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases - Jenner Matthew
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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases - Erstausgabe

2016

ISBN: 9783319327235

ID: 35204601

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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases
Autor:

Jenner Matthew

Titel:

Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases

ISBN-Nummer:

9783319327235

Detailangaben zum Buch - Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases


EAN (ISBN-13): 9783319327235
Erscheinungsjahr: 2016
Herausgeber: Springer International Publishing

Buch in der Datenbank seit 27.05.2016 15:09:51
Buch zuletzt gefunden am 12.01.2017 11:23:23
ISBN/EAN: 9783319327235

ISBN - alternative Schreibweisen:
978-3-319-32723-5

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