Monolithic Silicas in Separation Science - gebunden oder broschiert

EAN (ISBN-13): 9783527325757
ISBN (ISBN-10): 3527325751
Gebundene Ausgabe
Erscheinungsjahr: 2011
Herausgeber: Wiley-VCH
344 Seiten
Gewicht: 0,846 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 2009-04-11T16:42:57+02:00 (Berlin)
Detailseite zuletzt geändert am 2022-11-17T17:58:13+01:00 (Berlin)
ISBN/EAN: 9783527325757

ISBN - alternative Schreibweisen:
3-527-32575-1, 978-3-527-32575-7
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: unger, tanaka, mach, macht, nobu, nob, tana, wiley vch verlag gmbh, egid, klaus
Titel des Buches: science, vertrauen, applications concepts, séparation, monolith, unger

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Daten vom Verlag:

Autor/in: Klaus K. Unger; Nobuo Tanaka; Egidijus Machtejevas
Titel: Monolithic Silicas in Separation Science - Concepts, Syntheses, Characterization, Modeling and Applications
Verlag: Wiley-VCH; Wiley-VCH
344 Seiten
Erscheinungsjahr: 2011-01-14
Gedruckt / Hergestellt in Singapur.
Gewicht: 0,842 kg
Sprache: Englisch
145,00 € (DE)
149,10 € (AT)
Available
170mm x 240mm x 23mm

BB; Hardcover, Softcover / Chemie; Chromatographie; Verstehen; Chemie; Biochemie u. Chemische Biologie; Biochemistry (Chemical Biology); Biowissenschaften; Chemie; Chemistry; Chromatographie; Chromatographie / Trennverfahren; Chromatography / Separation Techniques; Genomforschung u. Proteomik; Genomics & Proteomics; Life Sciences; Chromatographie / Trennverfahren; Biochemie u. Chemische Biologie; Genomforschung u. Proteomik

Preface THE BASIC IDEA AND THE DRIVERS Definitions Monoliths as Heterogeneous Catalysts Monoliths in Chromatographic Separations Conclusion and Perspectives PART I: Preparation SYNTHESIS CONCEPTS AND PREPARATION OF SILICA MONOLITHS Introduction Background and Concepts Synthesis of Silica Monoliths Monolithic Columns Prepared in the Laboratory PREPARATION AND PROPERTIES OF VARIOUS TYPES OF MONOLITHIC SILICA STATIONARY PHASES FOR REVERSED-PHASE, HYDROPHILIC INTERACTION, AND ION-EXCHANGE CHROMATOGRAPHY BASED ON POLYMER-COATED MATERIALS Stationary Phases for Reversed-Phase Chromatography Stationary Phases for Hydrophilic-Interaction Chromatography Separations Stationary Phases for Ion-Exchange Separations Advantages of Polymer-Coated Monolithic Silica Columns PART II: Characterization and Modeling CHARACTERIZATION OF THE PORE STRUCTURE OF MONOLITHIC SILICAS Monolithic Silicas General Aspects Describing Porous Materials Characterization Methods of the Pore Structure of Monolithic Silicas Comparison of the Silica Monolith Mesopore-Characterization Data Comparison of the Silica Monolith Flow-Through Pore-Characterization Data MICROSCOPIC CHARACTERIZATIONS Introduction Preparation of Macroporous Silica Monolith Laser Scanning Confocal Microscope Observation Image Processing Fundamental Parameters Three-Dimensional Observation of Deformations in Confined Geometry MODELING CHROMATOGRAPHIC BAND BROADENING IN MONOLITHIC COLUMNS Introduction The General Plate-Height Model User of the General Plate-Height Model to Predict Band Broadening in TSM Structures Conclusion COMPARISON OF THE PERFORMANCE OF PARTICLE-PACKED AND MONOLITHIC COLUMNS IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY Introduction Basic Columns Properties Comparison of the Through-Pore Structures and Related Properties Thermodynamic Properties Kinetic Properties and Column Efficiency Conclusions PART III: Applications QUANTITATIVE STRUCTURE-RETENTION RELATIONSHIPS IN STUDIES OF MONOLITHIC MATERIALS Fundamentals of Quantitative Structure-Retention Relationships (QSSR) Quantitative Relationships between Analyte Hydrophobicity and Retention on Monolithic Columns QSSR Based on Structural Descriptors from Calculation Chemistry LSER on Monolithic Columns Concluding Remarks PERFORMANCE OF SILICA MONOLITHS FOR BASIC COMPOUNDS. SILANOL ACTIVITY Introduction Reproducibility of Commercial Monoliths for Analysis of Bases Activity of Monoliths towards Basic Solutes Contribution of Overload to Peak Shapes of Basic Solutes Van Deemter Plots for Commercial Monoliths Performance of Hybrid Capillary Silica Monoliths for Basic Compounds QUALITY CONTROL OF DRUGS Introduction Analysis of Pharmaceutics Natural Products Analysis Analysis Speed and Performance Method Transfer Separation of Complex Mixtures Monolithic Derivatives and Versatile Application Summary and Conclusions MONOLITHIC STATIONARY PHASES FOR FAST ION CHROMATOGRAPHY Fast Ion Chromatography Historical Development of Fast Ion Chromatography 3 Advantages of the Bimodal Porous Structure of the Silica Monolith Matrix Type and Properties of Silica Monolithic Columns Used in IC Modification of Silica Monoliths for IC Separations Operational Parameters Analytical Applications Future Work MONOLITHIC CHIRAL STATIONARY PHASES FOR LIQUID-PHASE ENANTIOSEPARATION TECHNIQUES Introduction Organic Monolithic Materials for the Separation of Enantiomers Silica-Based Monolithic Materials for the Separation of Enantiomers Summary of the Present State-of-the-Art and Problems to be Solved in the Future HIGH-SPEED AND HIGH-EFFICIENCY SEPARATIONS BY UTILIZING MONOLITHIC SILICA CAPILLARY COLUMNS Introduction Preparation of Monolithic Silica Capillary Columns Properties of Monolithic Silica Capillary Columns Monolithic Silica Capillary Columns for High-Efficiency Separations Monolithic Silica Capillary Columns for High-Speed Separations Future Considerations SILICA MONOLITHIC COLUMNS AND MASS SPECTROMETRY Introduction Offline Chromatography, LC MALDI MS Online ESI LC/MS/MS for Proteomics and Selected Reaction Monitoring (SRM) Online Reactors and Affinity Columns Coupled to Mass Spectrometry Conclusion SILICA MONOLITHS FOR SMALL-SCALE PURIFICATION OF DRUG-DISCOVERY COMPOUNDS Introduction Instrumental and Operating Considerations Preparative Separations and Sample Loading Purification of Drug-Discovery Compounds Conclusions MONOLITHIC SILICA COLUMNS IN MULTIDIMENSIONAL LC-MS FOR PROTEOMICS AND PEPTIDOMICS Introduction Liquid Chromatography as a Tool Box for Proteomics Selectivity of Columns for MD-LC Dimensions of Columns in MD-LC Monolithic Silica Columns Applications of Monolithic Silica in Proteomics - A Brief Survey Summary and Conclusions SILICA MONOLITHS IN SOLID-PHASE EXTRACTION AND SOLID-PHASE MICROEXTRACTION Introduction Extraction Process Extraction Platforms Applications Conclusion and Outlook