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Reactive Drug Metabolites, Volume 55 - Amit S. Kalgutkar, Deepak Dalvie, Dennis A. Smith, Gerd Folkers, Hugo Kubinyi, R. Scott Obach, Raimund Mannhold
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Amit S. Kalgutkar, Deepak Dalvie, Dennis A. Smith, Gerd Folkers, Hugo Kubinyi, R. Scott Obach, Raimund Mannhold:
Reactive Drug Metabolites, Volume 55 - neues Buch

9, ISBN: 9783527655762

ID: 100659783527655762

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes t Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training. Pharmacology, Medical Science, Reactive Drug Metabolites, Volume 55~~ Amit S. Kalgutkar, Deepak Dalvie, Dennis A. Smith, Gerd Folkers, Hugo Kubinyi, R. Scott Obach, Raimund Mannhold~~Pharmacology~~Medical Science~~9783527655762, en, Reactive Drug Metabolites, Volume 55, Amit S. Kalgutkar, Deepak Dalvie, Dennis A. Smith, Gerd Folkers, Hugo Kubinyi, R. Scott Obach, Raimund Mannhold, 9783527655762, Wiley-VCH, 09/06/2012, , , , Wiley-VCH, 09/06/2012

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Reactive Drug Metabolites, Volume 55 - Victor Malyshkin
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Victor Malyshkin:
Reactive Drug Metabolites, Volume 55 - neues Buch

ISBN: 9783527655762

ID: 9783527655762

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.; PDF \ Victor Malyshkin; Scientific, Technical and Medical > Pre-clinical medicine: basic sciences > Physiology > Metabolism, Springer Berlin Heidelberg

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Reactive Drug Metabolites als eBook Download von Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith - Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith:
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Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith eBooks > Belletristik > Erzählungen, Wiley-VCH

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Reactive Drug Metabolites - Raimund Mannhold;  Amit S. Kalgutkar;  Hugo Kubinyi;  Deepak Dalvie;  Gerd Folkers;  R. Scott Obach;  Douglas A. Smith
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Raimund Mannhold; Amit S. Kalgutkar; Hugo Kubinyi; Deepak Dalvie; Gerd Folkers; R. Scott Obach; Douglas A. Smith:
Reactive Drug Metabolites - Erstausgabe

2012, ISBN: 9783527655762

ID: 24995163

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Reactive Drug Metabolites - Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith:
Reactive Drug Metabolites - Erstausgabe

2012, ISBN: 9783527655762

ID: 24995163

[ED: 1], 1. Auflage, eBook Download (EPUB), eBooks, [PU: Wiley-VCH]

Neues Buch Lehmanns.de
Versandkosten:Download sofort lieferbar, , Versandkostenfrei innerhalb der BRD (EUR 0.00)
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(*) Derzeit vergriffen bedeutet, dass dieser Titel momentan auf keiner der angeschlossenen Plattform verfügbar ist.