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Tubulin-Binding Agents - Teresa Carlomagno
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Tubulin-Binding Agents - neues Buch

2009, ISBN: 9783540690368

ID: 691863365

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology. This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. Bücher > Fremdsprachige Bücher > Englische Bücher gebundene Ausgabe 26.06.2009, Springer, .200

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Tubulin-Binding Agents - Teresa Carlomagno
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Tubulin-Binding Agents - neues Buch

ISBN: 9783540690368

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This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-540-69036-8, Springer

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Tubulin-Binding Agents - Teresa Carlomagno
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Teresa Carlomagno:
Tubulin-Binding Agents - neues Buch

ISBN: 9783540690368

ID: 87815981

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology. This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Springer

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Tubulin-Binding Agents - Teresa Carlomagno
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Teresa Carlomagno:
Tubulin-Binding Agents - neues Buch

ISBN: 9783540690368

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - Bernhard Pfeiffer, Christian N. Kuzniewski, Christoph Wullschleger, and Karl-Heinz Altmann: Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships.- Ian Paterson and Gordon J. Florence: The Chemical Synthesis of Discodermolide.- J. Fernando Díaz, José Manuel Andreu, and Jesús Jiménez-Barbero: The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels.- Víctor M. Sánchez-Pedregal, and Christian Griesinger: The Tubulin-Binding Mode of MT Stabilizing and Destabilizing Agents studied by NMR.- James H. Nettles and Kenneth H. Downing: The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography.- Benoit Gigant, Anthony Cormier, Audrey Dorleans, Raimond B. G. Ravelli, Marcel Knossow: Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin.- Maurizio Botta, Stefano Forli, Matteo Magnani, Fabrizio Manetti: Molecular Modelling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents -, [SC: 0.00]

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ISBN: 9783540690368

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Chemistry; Medicinal Chemistry; Biochemistry, general; Cancer Research; Organic Chemistry; Analytical Chemistry Biochemistry, Destabilizing Agents, Microtubules, Stabilizing Agents, Tubulin-Binding Agents, chemistry, molecular modelling, organic chemistry, synthesis Books Book, Springer Science+Business Media

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Tubulin-Binding Agents
Autor:

Teresa Carlomagno

Titel:

Tubulin-Binding Agents

ISBN-Nummer:

9783540690368

Bernhard Pfeiffer, Christian N. Kuzniewski, Christoph Wullschleger, and Karl-Heinz Altmann: Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships.- Ian Paterson and Gordon J. Florence: The Chemical Synthesis of Discodermolide.- J. Fernando Díaz, José Manuel Andreu, and Jesús Jiménez-Barbero: The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels.- Víctor M. Sánchez-Pedregal, and Christian Griesinger: The Tubulin-Binding Mode of MT Stabilizing and Destabilizing Agents studied by NMR.- James H. Nettles and Kenneth H. Downing: The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography.- Benoit Gigant, Anthony Cormier, Audrey Dorleans, Raimond B. G. Ravelli, Marcel Knossow: Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin.- Maurizio Botta, Stefano Forli, Matteo Magnani, Fabrizio Manetti: Molecular Modelling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents

Detailangaben zum Buch - Tubulin-Binding Agents


EAN (ISBN-13): 9783540690368
ISBN (ISBN-10): 3540690360
Gebundene Ausgabe
Erscheinungsjahr: 2009
Herausgeber: Springer-Verlag GmbH
331 Seiten
Gewicht: 0,637 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 20.05.2009 17:20:40
Buch zuletzt gefunden am 10.02.2017 21:36:53
ISBN/EAN: 9783540690368

ISBN - alternative Schreibweisen:
3-540-69036-0, 978-3-540-69036-8

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