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A Computational Investigation of Selective DNA Methylation - Site and Sequence Specificity - Ekanayake, Kaushalya S. / Breton, Pierre R. Le
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Ekanayake, Kaushalya S. / Breton, Pierre R. Le:
A Computational Investigation of Selective DNA Methylation - Site and Sequence Specificity - Taschenbuch

2008, ISBN: 9783639052435

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 220 mm, 140, [GW: 200g], Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung, Interntational shipping

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A Computational Investigation of Selective DNA Methylation - Site and Sequence Specificity
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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A Computational Investigation of Selective DNA Methylation - Site and Sequence Specificity - Taschenbuch

2008, ISBN: 9783639052435

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens., [SC: 0.00], Neuware, gewerbliches Angebot, 220 mm, [GW: 200g]

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A Computational Investigation of Selective DNA Methylation - Kaushalya S. Ekanayake
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Kaushalya S. Ekanayake:
A Computational Investigation of Selective DNA Methylation - neues Buch

ISBN: 9783639052435

ID: 94d731abe7f7f94c20f2ec88348fdb68

Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Chemie, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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A Computational Investigation of Selective DNA Methylation - Pierre R. Lebreton
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Pierre R. Lebreton:
A Computational Investigation of Selective DNA Methylation - Taschenbuch

ISBN: 9783639052435

ID: 9783639052435

A Computational Investigation of Selective DNA Methylation A-Computational-Investigation-of-Selective-DNA-Methylation~~Pierre-R-Lebreton Science>Chemistry>Chemistry Paperback, VDM Verlag Dr. Mueller E.K.

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A Computational Investigation of Selective DNA Methylation - Kaushalya S. Ekanayake; Pierre R. Le Breton
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A Computational Investigation of Selective DNA Methylation - neues Buch

2008, ISBN: 9783639052435

ID: 9583786

Site and Sequence Specificity, unbekannt, Buch, [PU: VDM Verlag Dr. Müller]

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A Computational Investigation of Selective DNA Methylation

Many alkylating agents covalently bind to nucleophilic positions in cellular DNA, causing DNA damage. This has been directly linked to mutagenic and carcinogenic activity. Methane diazonium ions, which are the reactive intermediates formed from several potent carcinogenic methylating agents including methyl nitrosourea, can simultaneously react with different DNA sites. Ab initio quantum mechanical SCF and density functional methods have been employed to examine diazonium ion-DNA base transition states and diazonium ion-oligonucleotide model transition states in the gas phase and in an aqueous environment. This characterization of transition states was used to provide descriptions of site and sequence specific reaction patterns of methane diazonium ions at different DNA bases and at different guanine sites in sequences containing multiply stacked guanines. This work provides a computational methodology that, in principle, can describe the DNA reaction specificity of a large number of mutagens and carcinogens.

Detailangaben zum Buch - A Computational Investigation of Selective DNA Methylation


EAN (ISBN-13): 9783639052435
ISBN (ISBN-10): 3639052439
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2008
Herausgeber: VDM Verlag
140 Seiten
Gewicht: 0,225 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 26.02.2007 12:52:08
Buch zuletzt gefunden am 16.07.2017 04:43:20
ISBN/EAN: 9783639052435

ISBN - alternative Schreibweisen:
3-639-05243-9, 978-3-639-05243-5


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