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Anti-apoptotic strategies of M. tuberculosis - Kripa Jalapathy
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Kripa Jalapathy:
Anti-apoptotic strategies of M. tuberculosis - neues Buch

ISBN: 9783639184747

ID: 09540dea0359bfbfc3dbe286d16431d5

The role of a novel protein, NlaA Mycobacterium tuberculosis, one of most successful pathogens of mankind, infects one-third of the global population claiming nearly two million lives every year. The pathogen exhibits extraordinary capacities to evade host responses to survive within the host. One of the hallmarks is its ability to inhibit apoptosis to promote intracellular survival. Understanding the mechanism of inhibition of infection-induced apoptosis and the signaling pathway involved may help reveal salient components of host defense. The study described in this thesis dissects the ability of this deadly pathogen in hijacking the host responses to infection and how this can be exploited for design of better vaccines against Tuberculosis. The crux of the thesis is the identification of a new gene of M. tuberculosis, nlaA, and its gene product, a secreted protein. The thesis further describes the design of a novel attenuated vaccine, by knocking-out the gene from M. tuberculosis. The vaccine candidate thus developed is attenuated, inflicts less pathological changes in the organs of infected mice and protects against experimental tuberculosis. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-639-18474-7, VDM Verlag Dr. Müller

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Anti-apoptotic strategies of M. tuberculosis - The role of a novel protein, NlaA
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Anti-apoptotic strategies of M. tuberculosis - The role of a novel protein, NlaA - Taschenbuch

2009, ISBN: 9783639184747

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Mycobacterium tuberculosis, one of most successful pathogens of mankind, infects one-third of the global population claiming nearly two million lives every year. The pathogen exhibits extraordinary capacities to evade host responses to survive within the host. One of the hallmarks is its ability to inhibit apoptosis to promote intracellular survival. Understanding the mechanism of inhibition of infection-induced apoptosis and the signaling pathway involved may help reveal salient components of host defense. The study described in this thesis dissects the ability of this deadly pathogen in hijacking the host responses to infection and how this can be exploited for design of better vaccines against Tuberculosis. The crux of the thesis is the identification of a new gene of M. tuberculosis, nlaA, and its gene product, a secreted protein. The thesis further describes the design of a novel attenuated vaccine, by knocking-out the gene from M. tuberculosis. The vaccine candidate thus developed is attenuated, inflicts less pathological changes in the organs of infected mice and protects against experimental tuberculosis., [SC: 0.00], Neuware, gewerbliches Angebot

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Anti-apoptotic strategies of M. tuberculosis - The role of a novel protein, NlaA
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Anti-apoptotic strategies of M. tuberculosis - The role of a novel protein, NlaA - Taschenbuch

2009, ISBN: 9783639184747

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Mycobacterium tuberculosis, one of most successful pathogens of mankind, infects one-third of the global population claiming nearly two million lives every year. The pathogen exhibits extraordinary capacities to evade host responses to survive within the host. One of the hallmarks is its ability to inhibit apoptosis to promote intracellular survival. Understanding the mechanism of inhibition of infection-induced apoptosis and the signaling pathway involved may help reveal salient components of host defense. The study described in this thesis dissects the ability of this deadly pathogen in hijacking the host responses to infection and how this can be exploited for design of better vaccines against Tuberculosis. The crux of the thesis is the identification of a new gene of M. tuberculosis, nlaA, and its gene product, a secreted protein. The thesis further describes the design of a novel attenuated vaccine, by knocking-out the gene from M. tuberculosis. The vaccine candidate thus developed is attenuated, inflicts less pathological changes in the organs of infected mice and protects against experimental tuberculosis., Neuware, gewerbliches Angebot

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Anti-apoptotic strategies of M. tuberculosis - Kripa Jalapathy
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Kripa Jalapathy:
Anti-apoptotic strategies of M. tuberculosis - neues Buch

ISBN: 9783639184747

ID: 120535733

Mycobacterium tuberculosis, one of most successful pathogens of mankind, infects one-third of the global population claiming nearly two million lives every year. The pathogen exhibits extraordinary capacities to evade host responses to survive within the host. One of the hallmarks is its ability to inhibit apoptosis to promote intracellular survival. Understanding the mechanism of inhibition of infection-induced apoptosis and the signaling pathway involved may help reveal salient components of host defense. The study described in this thesis dissects the ability of this deadly pathogen in hijacking the host responses to infection and how this can be exploited for design of better vaccines against Tuberculosis. The crux of the thesis is the identification of a new gene of M. tuberculosis, nlaA, and its gene product, a secreted protein. The thesis further describes the design of a novel attenuated vaccine, by knocking-out the gene from M. tuberculosis. The vaccine candidate thus developed is attenuated, inflicts less pathological changes in the organs of infected mice and protects against experimental tuberculosis. The role of a novel protein, NlaA Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, VDM

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Anti-apoptotic strategies of M. tuberculosis
Autor:

Kripa Jalapathy

Titel:

Anti-apoptotic strategies of M. tuberculosis

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Detailangaben zum Buch - Anti-apoptotic strategies of M. tuberculosis


EAN (ISBN-13): 9783639184747
Taschenbuch
Erscheinungsjahr: 2009
Herausgeber: VDM Verlag Dr. Müller

Buch in der Datenbank seit 04.11.2015 21:05:10
Buch zuletzt gefunden am 14.04.2017 21:32:24
ISBN/EAN: 9783639184747

ISBN - alternative Schreibweisen:
978-3-639-18474-7


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