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Cell Biology of the Axon - Edward Koenig
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Edward Koenig:
Cell Biology of the Axon - neues Buch

ISBN: 9783642030192

ID: 232663

Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains, (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons, (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGFs role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies, (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation, (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration.Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axons intrinsic makeup and capacities.[PU:Springer-Verlag], [PU: Springer, Berlin/Heidelberg/New York, NY]

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Cell Biology of the Axon - Edward Koenig
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ID: 203179783642030192

Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelin Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF's role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf Adult, Other Sciences, Cell Biology of the Axon~~ Edward Koenig~~Adult~~Other Sciences~~9783642030192, en, Cell Biology of the Axon, Edward Koenig, 9783642030192, Springer, 09/01/2009, , , , Springer, 09/01/2009

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Cell Biology of the Axon - Edward Koenig
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ISBN: 9783642030192

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Life Sciences; Cell Biology; Biochemistry, general; Neurochemistry Activation, Chaperone, Elongation, Microtubule organization, Nervous System, RNA, cell biology, genes, growth cones, myosin, neurons, protein complexes, proteins, regulation, translation Books eBook, Springer Science+Business Media

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Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. This is the first complete overview on axonal biology and includes the latest advances. Versandkosten: EUR 0.00
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Cell Biology of the Axon - Koenig, Edward
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Koenig, Edward:
Cell Biology of the Axon - neues Buch

2009, ISBN: 364203019X

ID: 9783642030192

In englischer Sprache. Verlag: Springer Berlin, Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. This is the first complete overview on axonal biology and includes the latest advances. PC-PDF, 360 Seiten, XVI Seiten, 360 Seiten, [GR: 9672 - Nonbooks, PBS / Biologie/Mikrobiologie], [SW: - Mikrobiologie (nicht-medizinisch) ], [Ausgabe: 2009][PU:Springer Berlin], [PU: Springer, Berlin/Heidelberg/New York, NY]

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Cell Biology of the Axon - Edward Koenig;  Edward Koenig
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Edward Koenig; Edward Koenig:
Cell Biology of the Axon - Erstausgabe

2009, ISBN: 9783642030192

ID: 21777429

[ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Springer-Verlag]

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Detailangaben zum Buch - Cell Biology of the Axon


EAN (ISBN-13): 9783642030192
ISBN (ISBN-10): 364203019X
Erscheinungsjahr: 2009
Herausgeber: Springer Berlin
350 Seiten
Sprache: eng/Englisch

Buch in der Datenbank seit 20.09.2011 22:18:37
Buch zuletzt gefunden am 26.03.2018 00:25:07
ISBN/EAN: 9783642030192

ISBN - alternative Schreibweisen:
3-642-03019-X, 978-3-642-03019-2


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