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Molecular Analysis of B Lymphocyte Development and Activation (Current Topics in Microbiology and Immunology) - Harinder Singh
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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Harinder Singh:
Molecular Analysis of B Lymphocyte Development and Activation (Current Topics in Microbiology and Immunology) - Taschenbuch

2014, ISBN: 3642421881

Paperback, [EAN: 9783642421884], Springer, Springer, Book, [PU: Springer], 2014-11-28, Springer, TheBlymphocytelineagerepresentsaleadingsystemforexploring- lecularmechanismsthatunderliecellfatespecification,differentiationand cellular activation. In the past five years major advances have been achievedintheanalysisofearlyBcelldevelopment,AIDdependentclass switchrecombinationaswellassomatichypermutationandBlimp-1re- latedplasmacelldifferentiation. Manyofthesefindingsandtheirimpli- tionsarecoveredinthisvolume. Twoemergentareasofresearchthatare includedinthecontributionsfocusonthepre-BCRandIkaros-familyp- teins. Thepre-BCRisanunusualmoleculardevicethatisusedtoexecute acriticaldevelopmentalcheckpointintheBlineage. Itsmechanismof- tion in relationto the pre-TCR and the mature antigen receptors (BCR, TCR)isofconsiderableinterest. Ikaros-familyproteinsappeartofunction viarecruitingtargetgenestodomainsofcentromericheterochromatinin the nucleus. Initially discovered in lymphocytes, they represent a novel system of gene regulationvia nuclearcompartmentalization. Finally, the volumeincludesachapteronWntsignalinginlymphopoiesis. Analysisof thisevolutionallyconservedpathwaywhichregulatescellularproliferation anddifferentiationindiversedevelopmentalcontextsbenefitedenormo- lyfromthediscoveryoftheLEF/TCFfamilyoffactorsinlymphocyticl- eages. ThisvolumeisdedicatedtothememoryofEugeniaSpanopoulou,ac- leagueandahighlyvaluedmemberofourscientificcommunity. Itc- tainsachapteronthebiochemistryofV(D)JrecombinationthatEugenia co-authoredwithDavidSchatz. Obituary Eugenia Spanopoulou was an extraordinary person and scientist. Her enormousintelligenceandenergysparkedimportantscientificdiscoveries, andvaultedhertoapointofbreathtakingpotential-apotentialabruptly erasedattheageof37withthecrashofSwissairflight111onSeptember 3,1998. Lostwithherwereherhusband,AndrewHodtsev,andyoungson, Platon. Eugeniawaspassionatelyinterestedinunderstandingthemolecular- sisofdevelopmentandchoseashermodelsystemthedevelopmentofB andTlymphocytes. Shebeganbystudyingthetranscriptionalregulation oftheTcell-specificge, 270852, Immunology, 270847, Diseases & Disorders, 270842, Internal Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 270938, Pathology, 270906, Other Branches of Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 922572, Medical Sciences A-Z, 922574, Accident & Emergency Medicine, 270911, Anaesthetics, 270844, Cardiovascular, 922594, Clinical Psychology & Psychotherapy, 922596, Counselling & Therapy, 922606, Dermatology, 922610, Diseases & Disorders, 922632, Elderly Care, 270864, Endocrinology, 922638, ENT, 270928, Forensic Medicine, 270867, Gastroenterology, 922654, Health Psychology, 922664, Neurology, 922676, Ophthalmology, 922678, Orthopaedic & Fractures, 922682, Paediatrics, 922684, Pathology, 922700, Pre-clinical Medicine, 270948, Psychiatry, 922718, Psychotherapy & Clinical Psychology, 922720, Public Health & Preventive Medicine, 922730, Radiology & Medical Imaging, 270889, Renal Medicine, 270890, Respiratory Medicine, 270891, Rheumatology, 922752, Sports Injuries & Medicine, 922754, Surgery, 270892, Urology, 922532, Medicine, 57, Science & Nature, 1025612, Subjects, 266239, Books, 571382, Medical Sciences A-Z, 571384, Anaesthetics, 571400, Cardiovascular, 571334, Diseases & Disorders, 571390, Gynaecology & Obstetrics, 571386, Neurology, 571316, Orthopaedic & Fractures, 571388, Paediatrics, 571362, Pathology, 571392, Psychiatry, 571290, Public Health & Preventive Medicine, 571350, Radiology & Medical Imaging, 571280, Research & Equipment, 571310, Surgery, 564356, Medicine & Nursing, 564334, Scientific, Technical & Medical, 1025612, Subjects, 266239, Books

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Molecular Analysis of B Lymphocyte Development and Activation - Harinder Singh; Rudolf Grosschedl
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Biomedicine; Immunology B cell receptor, DNA-binding proteins, biochemistry, cell, class switch recombination, cytokine, cytokine receptors, gene, genes, immunoglobulin, protein, proteins, transcriptional regulators Books, Springer Nature

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Molecular Analysis of B Lymphocyte Development and Activation - Harinder Singh
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Molecular Analysis of B Lymphocyte Development and Activation - Taschenbuch

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Molecular Analysis of B Lymphocyte Development and Activation Molecular-Analysis-of-B-Lymphocyte-Development-and-Activation~~Harinder-Singh Medicine>Medicine>Public Health Paperback, Springer Berlin Heidelberg

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Molecular Analysis of B Lymphocyte Development and Activation - Harinder Singh; Rudolf Grosschedl
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Molecular Analysis of B Lymphocyte Development and Activation

TheBlymphocytelineagerepresentsaleadingsystemforexploring- lecularmechanismsthatunderliecellfatespecification,differentiationand cellular activation. In the past five years major advances have been achievedintheanalysisofearlyBcelldevelopment,AIDdependentclass switchrecombinationaswellassomatichypermutationandBlimp-1re- latedplasmacelldifferentiation. Manyofthesefindingsandtheirimpli- tionsarecoveredinthisvolume. Twoemergentareasofresearchthatare includedinthecontributionsfocusonthepre-BCRandIkaros-familyp- teins. Thepre-BCRisanunusualmoleculardevicethatisusedtoexecute acriticaldevelopmentalcheckpointintheBlineage. Itsmechanismof- tion in relationto the pre-TCR and the mature antigen receptors (BCR, TCR)isofconsiderableinterest. Ikaros-familyproteinsappeartofunction viarecruitingtargetgenestodomainsofcentromericheterochromatinin the nucleus. Initially discovered in lymphocytes, they represent a novel system of gene regulationvia nuclearcompartmentalization. Finally, the volumeincludesachapteronWntsignalinginlymphopoiesis. Analysisof thisevolutionallyconservedpathwaywhichregulatescellularproliferation anddifferentiationindiversedevelopmentalcontextsbenefitedenormo- lyfromthediscoveryoftheLEF/TCFfamilyoffactorsinlymphocyticl- eages. ThisvolumeisdedicatedtothememoryofEugeniaSpanopoulou,ac- leagueandahighlyvaluedmemberofourscientificcommunity. Itc- tainsachapteronthebiochemistryofV(D)JrecombinationthatEugenia co-authoredwithDavidSchatz. Obituary Eugenia Spanopoulou was an extraordinary person and scientist. Her enormousintelligenceandenergysparkedimportantscientificdiscoveries, andvaultedhertoapointofbreathtakingpotential-apotentialabruptly erasedattheageof37withthecrashofSwissairflight111onSeptember 3,1998. Lostwithherwereherhusband,AndrewHodtsev,andyoungson, Platon. Eugeniawaspassionatelyinterestedinunderstandingthemolecular- sisofdevelopmentandchoseashermodelsystemthedevelopmentofB andTlymphocytes. Shebeganbystudyingthetranscriptionalregulation oftheTcell-specificge

Detailangaben zum Buch - Molecular Analysis of B Lymphocyte Development and Activation


EAN (ISBN-13): 9783642421884
ISBN (ISBN-10): 3642421881
Taschenbuch
Erscheinungsjahr: 2014
Herausgeber: Springer Berlin

Buch in der Datenbank seit 06.02.2015 16:15:10
Buch zuletzt gefunden am 03.05.2018 11:45:35
ISBN/EAN: 9783642421884

ISBN - alternative Schreibweisen:
3-642-42188-1, 978-3-642-42188-4


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