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Brittle Fracture Index as a Tool for Tablet Binder Selection - Radha Krishna Yedavalli
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Radha Krishna Yedavalli:

Brittle Fracture Index as a Tool for Tablet Binder Selection - Taschenbuch

ISBN: 9783659271601

ID: 9783659271601

The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an inbuilt defect which will help in propagation of crack into the tablet and enable capping and lamination. The tensile strengths of tablet with hole and without hole are used in calculating BFI. The so calculated BFI is correlated to the dissolution profile of the formulations and the most stable formulation can be formed. Here all the formulations showed excellent results minimum BFI values except Metformin HCl and Paracetamol giving high BFI values indicating susceptibility to Capp or laminate where as Efavirenz and Ciprofloxacin with low BFI values and less susceptible to Capp or laminate. Whereas Metformin has no dissolution failure but Efavirenz has dissolution issues. Brittle Fracture Index as a Tool for Tablet Binder Selection: The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an inbuilt defect which will help in propagation of crack into the tablet and enable capping and lamination. The tensile strengths of tablet with hole and without hole are used in calculating BFI. The so calculated BFI is correlated to the dissolution profile of the formulations and the most stable formulation can be formed. Here all the formulations showed excellent results minimum BFI values except Metformin HCl and Paracetamol giving high BFI values indicating susceptibility to Capp or laminate where as Efavirenz and Ciprofloxacin with low BFI values and less susceptible to Capp or laminate. Whereas Metformin has no dissolution failure but Efavirenz has dissolution issues., LAP Lambert Academic Publishing

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Brittle Fracture Index as a Tool for Tablet Binder Selection - Yedavalli Radha Krishna, L Sai Koundinya
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Yedavalli Radha Krishna, L Sai Koundinya:

Brittle Fracture Index as a Tool for Tablet Binder Selection - neues Buch

2014, ISBN: 9783659271601

ID: 9200000027129136

The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an in..., The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an inbuilt defect which will help in propagation of crack into the tablet and enable capping and lamination. The tensile strengths of tablet with hole and without hole are used in calculating BFI. The so calculated BFI is correlated to the dissolution profile of the formulations and the most stable formulation can be formed. Here all the formulations showed excellent results minimum BFI values except Metformin HCl and Paracetamol giving high BFI values indicating susceptibility to Capp or laminate where as Efavirenz and Ciprofloxacin with low BFI values and less susceptible to Capp or laminate. Whereas Metformin has no dissolution failure but Efavirenz has dissolution issues.Taal: Engels; Afmetingen: 10x229x152 mm; Gewicht: 249,00 gram; Verschijningsdatum: maart 2014; ISBN10: 3659271608; ISBN13: 9783659271601; , Engelstalig | Paperback | 2014, Studie & Management, Medisch & Gezondheid, Farmacologie, Lap Lambert Academic Publishing

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Brittle Fracture Index as a Tool for Tablet Binder Selection (Paperback) - Yedavalli Radha Krishna, L Sai Koundinya, Salomy Sanjana
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Yedavalli Radha Krishna, L Sai Koundinya, Salomy Sanjana:
Brittle Fracture Index as a Tool for Tablet Binder Selection (Paperback) - Taschenbuch

2014

ISBN: 3659271608

ID: 21229032325

[EAN: 9783659271601], Neubuch, [PU: LAP Lambert Academic Publishing, United States], Language: English . Brand New Book ***** Print on Demand *****.The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an inbuilt defect which will help in propagation of crack into the tablet and enable capping and lamination. The tensile strengths of tablet with hole and without hole are used in calculating BFI. The so calculated BFI is correlated to the dissolution profile of the formulations and the most stable formulation can be formed. Here all the formulations showed excellent results minimum BFI values except Metformin HCl and Paracetamol giving high BFI values indicating susceptibility to Capp or laminate where as Efavirenz and Ciprofloxacin with low BFI values and less susceptible to Capp or laminate. Whereas Metformin has no dissolution failure but Efavirenz has dissolution issues.

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Brittle Fracture Index as a Tool for Tablet Binder Selection - Radha Krishna Yedavalli
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Radha Krishna Yedavalli:
Brittle Fracture Index as a Tool for Tablet Binder Selection - neues Buch

ISBN: 9783659271601

ID: 26ebadce56196c782fb8a2689bc7ac73

The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an inbuilt defect which will help in propagation of crack into the tablet and enable capping and lamination. The tensile strengths of tablet with hole and without hole are used in calculating BFI. The so calculated BFI is correlated to the dissolution profile of the formulations and the most stable formulation can be formed. Here all the formulations showed excellent results minimum BFI values except Metformin HCl and Paracetamol giving high BFI values indicating susceptibility to Capp or laminate where as Efavirenz and Ciprofloxacin with low BFI values and less susceptible to Capp or laminate. Whereas Metformin has no dissolution failure but Efavirenz has dissolution issues. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Medizin / Pharmazie

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Brittle Fracture Index as a Tool for Tablet Binder Selection - Radha Krishna Yedavalli, Sai Koundinya L., Sanjana Salomy
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Radha Krishna Yedavalli, Sai Koundinya L., Sanjana Salomy:
Brittle Fracture Index as a Tool for Tablet Binder Selection - Taschenbuch

2014, ISBN: 3659271608

Paperback, [EAN: 9783659271601], LAP LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing, Book, [PU: LAP LAMBERT Academic Publishing], 2014-03-17, LAP LAMBERT Academic Publishing, 948626, Pharmacology, 51271011, Cardiovascular, 51276011, Chemistry, 51273011, Clinical, 51272011, Drug Delivery Systems, 948544, Drug Guides, 51267011, Molecular, 51270011, Neuropsychopharmacology, 948630, Pain Medicine, 51269011, Pharmacodynamics, 948632, Pharmacy, 51274011, Product Development, 51268011, Reference, 51275011, Research, 948634, Toxicology, 948300, Medical Books, 927726, Subjects, 916520, Books, 957184, Pharmacology, 956786, Drug Guides, 957188, Pain Medicine, 957190, Pharmacy, 957192, Toxicology, 956868, Medicine, 956280, Science & Math, 927726, Subjects, 916520, Books

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Brittle Fracture Index as a Tool for Tablet Binder Selection
Autor:

Yedavalli, Radha Krishna; L., Sai Koundinya; Salomy, Sanjana

Titel:

Brittle Fracture Index as a Tool for Tablet Binder Selection

ISBN-Nummer:

9783659271601

The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which ar....

Detailangaben zum Buch - Brittle Fracture Index as a Tool for Tablet Binder Selection


EAN (ISBN-13): 9783659271601
ISBN (ISBN-10): 3659271608
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2014
Herausgeber: AV Akademikerverlag GmbH & Co. KG.

Buch in der Datenbank seit 15.05.2014 15:07:48
Buch zuletzt gefunden am 08.01.2017 11:24:04
ISBN/EAN: 9783659271601

ISBN - alternative Schreibweisen:
3-659-27160-8, 978-3-659-27160-1

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