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The Molecular Biology of Poliovirus
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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The Molecular Biology of Poliovirus - Taschenbuch

2011, ISBN: 9783709174678

[ED: Taschenbuch / Paperback], [PU: Springer, Berlin Springer, Wien], AUSFÜHRLICHERE BESCHREIBUNG: Years ago when we were asked to write a book on the present-day knowledge of the molecular biology of poliovirus, we did not expect that such an apparently simple task could involve so much time and effort. Our writing was hampered by the fact that both of us are full time "workers", so that this monograph is mainly a spare time expedience. The main attention of this book focuses on a detailed review of the molecular biology of poliovirus and especially on the advances of the last decade medical and environmental aspects are only briefly mentioned. Observations from older studies are considered in view of more recent information. Some of the older ob servations provided fundamental insights and paved the way for present day research too often such data has been neglected or independently rediscovered. Today, poliovirus research has again attracted considerable interest. High points gained within the last few years were the elucidation of the complete nucleotide sequences of the RNAs of the three poliovinls serotypes and the corresponding vaccine strains, the demonstration of genome evolution during transmission of poliovirus in an epidemic, further characterization of the antigenic sites on the virus particle and of the antigenic drift, characterization of alternate conforma tional states of the virion capsid, the development of monoclonal antibodies against some of the virus proteins, observations on the role of the plasma membrane, cytoskeleton, and cytoplasmic membranes as mediators in the virus induced redirection of the synthetic machinery of the host cell, and characteriza INHALT: I: The Poliovirus.- 1. History.- I. Introduction.- II. Early History-Occasional Nonepidemic Cases of Poliomyelitis.- III. The 18th and 19th Centuries: Polioepidemics, Poliomyelitis Is Described as a Clinical Entity.- IV. Early 20th Century: Research on Polio Begins, Virology Is still a Clinical Discipline.- V. The Development of Vaccines Against the Poliomyelitis Virus.- VI. The Fifties and the Advent of Molecular Biology.- VII. Advances in Polio Research During the Past Two Decades.- 2. Classification.- I. General Considerations.- A. Nature of the Genome.- B. The Cryptogram.- II. The Distinguishing Features of Picornaviruses.- III. Comparison of Different Picornavirus Genera.- A. Disease Aspects.- B. Serotypes.- C. Physical Properties.- D. Relative Relatedness to Polioviruses.- 3. Composition and Structure of the Virion.- I. Introduction.- II. Composition and Physical Properties of the Virion.- III. Overall Architecture of the Viral Capsid.- A. Building Blocks.- 1. Functional Requirements.- 2. Biological Arguments of Building Block Economy and Efficiency of Assembly.- 3. Thermodynamic Forces and Structural Consequences.- B. The Geometric Design: The Icosahedron.- 1. Helical Tubes Versus Spherical Shells.- 2. Cubic Symmetries, the Platonic Polyhedra.- 3. The Icosahedron.- a) Advantages of Icosahedral Symmetry.- b) Limitations of the Icosahedral Skeleton as a Model for Virus Structure.- c) Related Regular Polyhedra with Icosahedral Symmetry.- d) The Bonding Pattern of an Icosahedral Lattice.- C. Experimental Evidence that the Poliovirus Capsid Is an Icosahedral Lattice.- 1. X-Ray Diffraction Studies.- 2. Electron Microscopic Observations.- 3. Resolving the 32 or 60 Capsomers Controversy.- 4. Similar Construction Principles for Picornaviruses and the Small Plant Viruses.- IV. Characterization of the Building Blocks: The Capsid Proteins.- A. Separation and Identification.- B. Amino Acid Composition and Sequence.- C. Microheterogeneity.- V. Relative Localization of the Viral Proteins in the Capsid and Bonds Involved.- A. General Reflections.- 1. Geometric Restrictions.- 2. Structural Principles Borrowed from Plant Picornaviruses.- 3. Implications for the Capsid Features of Poliovirus: The Concept of a Rigid Capsid Backbone and Variable Surface Protrusions.- B. Experimental Results.- 1. Specific Chemical Modifications of Capsid Proteins.- 2. Chemical Crosslinking of Capsid Proteins.- 3. UV Irradiation of Poliovirus.- VI. The Dissociation of Poliovirus.- A. Breakdown During Preparatory Procedures for Electron Microscopy.- B. Alkaline Degradation.- C. Heat Degradation.- D. Guanidine Degradation.- E. Urea Degradation.- F. Reassociation of Poliovirus from Products of Urea Degradation.- G. Conclusions.- VII. Conformational Forms of the Poliovirus Capsid.- A. Poliovirus Capsid Structures During Early Interactions with the Host Cell and upon Experimentally Induced Disruption: Two Conformational States of the Shell.- B. Viral Structures During Maturation.- C. Two Distinct, Reversibly Interconvertible Conformational States of Intact Poliovirions.- D. Conformational Alterations Monitored by Changes in the Intrinsic and Induced Fluorescence of Poliovirus Components.- E. Dense Particles.- F. Possible Functions of the Alternate Conformational States of the Poliovirus Capsid.- VIII. Antigenicity.- A. The Main Poliovirus Antigenic Sites: The D- and C-Antigenic States.- 1. Attempts to Identify the C- and D-Antigenic Determinants in Terms of the Constituent Capsid Proteins with Polyclonal Antisera.- 2. Studies with Monoclonal Antibodies.- B. Other, Minor Antigenic Sites on Poliovirus.- C. Serodifferentiation of Polioviruses.- IX. Summary.- A. Composition.- B. Structure.- C. The Capsid Proteins.- 1. Number of Peptides and Type of Association on the Structure Units.- 2. Relative Localizations.- 3. Heterogeneity.- D. Two Conformational States of the Capsid.- E. Antigenicity.- 4. Structure and Function of the Genome.- II. Genome Structure.- A. Char, Neuware, gewerbliches Angebot, H: 235mm, B: 155mm

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The Molecular Biology of Poliovirus - Koch, F. / Koch, G.
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[EAN: 9783709174678], Neubuch, Publisher/Verlag: Springer, Wien | Years ago when we were asked to write a book on the present-day knowledge of the molecular biology of poliovirus, we did not expect that such an apparently simple task could involve so much time and effort. Our writing was hampered by the fact that both of us are full time "workers", so that this monograph is mainly a spare time expedience. The main attention of this book focuses on a detailed review of the molecular biology of poliovirus and especially on the advances of the last decade; medical and environmental aspects are only briefly mentioned. Observations from older studies are considered in view of more recent information. Some of the older ob servations provided fundamental insights and paved the way for present day research; too often such data has been neglected or independently rediscovered. Today, poliovirus research has again attracted considerable interest. High points gained within the last few years were the elucidation of the complete nucleotide sequences of the RNAs of the three poliovinls serotypes and the corresponding vaccine strains, the demonstration of genome evolution during transmission of poliovirus in an epidemic, further characterization of the antigenic sites on the virus particle and of the antigenic drift, characterization of alternate conforma tional states of the virion capsid, the development of monoclonal antibodies against some of the virus proteins, observations on the role of the plasma membrane, cytoskeleton, and cytoplasmic membranes as mediators in the virus induced redirection of the synthetic machinery of the host cell, and characteriza | I: The Poliovirus.- 1. History.- I. Introduction.- II. Early History-Occasional Nonepidemic Cases of Poliomyelitis.- III. The 18th and 19th Centuries: Polioepidemics, Poliomyelitis Is Described as a Clinical Entity.- IV. Early 20th Century: Research on Polio Begins, Virology Is still a Clinical Discipline.- V. The Development of Vaccines Against the Poliomyelitis Virus.- VI. The Fifties and the Advent of Molecular Biology.- VII. Advances in Polio Research During the Past Two Decades.- 2. Classification.- I. General Considerations.- A. Nature of the Genome.- B. The Cryptogram.- II. The Distinguishing Features of Picornaviruses.- III. Comparison of Different Picornavirus Genera.- A. Disease Aspects.- B. Serotypes.- C. Physical Properties.- D. Relative Relatedness to Polioviruses.- 3. Composition and Structure of the Virion.- I. Introduction.- II. Composition and Physical Properties of the Virion.- III. Overall Architecture of the Viral Capsid.- A. Building Blocks.- 1. Functional Requirements.- 2. Biological Arguments of Building Block Economy and Efficiency of Assembly.- 3. Thermodynamic Forces and Structural Consequences.- B. The Geometric Design: The Icosahedron.- 1. Helical Tubes Versus Spherical Shells.- 2. Cubic Symmetries, the Platonic Polyhedra.- 3. The Icosahedron.- a) Advantages of Icosahedral Symmetry.- b) Limitations of the Icosahedral Skeleton as a Model for Virus Structure.- c) Related Regular Polyhedra with Icosahedral Symmetry.- d) The Bonding Pattern of an Icosahedral Lattice.- C. Experimental Evidence that the Poliovirus Capsid Is an Icosahedral Lattice.- 1. X-Ray Diffraction Studies.- 2. Electron Microscopic Observations.- 3. Resolving the 32 or 60 Capsomers Controversy.- 4. Similar Construction Principles for Picornaviruses and the Small Plant Viruses.- IV. Characterization of the Building Blocks: The Capsid Proteins.- A. Separation and Identification.- B. Amino Acid Composition and Sequence.- C. Microheterogeneity.- V. Relative Localization of the Viral Proteins in the Capsid and Bonds Involved.- A. General Reflections.- 1. Geometric Restrictions.- 2. Structural Principles Borrowed from Plant Picornaviruses.- 3. Implications for the Capsid Features of Poliovirus: The Concept of a Rigid Capsid Backbone and Variable Surface Protrusions.- B. Experimental Results.- 1. Specific Chemical Modifications

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The Molecular Biology of Poliovirus - F. Koch
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The Molecular Biology of Poliovirus - neues Buch

ISBN: 9783709174678

ID: 217d3a7e1fea83573c7900b5e4b85252

Years ago when we were asked to write a book on the present-day knowledge of the molecular biology of poliovirus, we did not expect that such an apparently simple task could involve so much time and effort. Our writing was hampered by the fact that both of us are full time "workers", so that this monograph is mainly a spare time expedience. The main attention of this book focuses on a detailed review of the molecular biology of poliovirus and especially on the advances of the last decade medical and environmental aspects are only briefly mentioned. Observations from older studies are considered in view of more recent information. Some of the older ob servations provided fundamental insights and paved the way for present day research too often such data has been neglected or independently rediscovered. Today, poliovirus research has again attracted considerable interest. High points gained within the last few years were the elucidation of the complete nucleotide sequences of the RNAs of the three poliovinls serotypes and the corresponding vaccine strains, the demonstration of genome evolution during transmission of poliovirus in an epidemic, further characterization of the antigenic sites on the virus particle and of the antigenic drift, characterization of alternate conforma tional states of the virion capsid, the development of monoclonal antibodies against some of the virus proteins, observations on the role of the plasma membrane, cytoskeleton, and cytoplasmic membranes as mediators in the virus induced redirection of the synthetic machinery of the host cell, and characteriza Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Biologie / Biochemie & Biophysik

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The Molecular Biology of Poliovirus - Koch, Friedrich/ Koch, Gebhard
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Koch, Friedrich/ Koch, Gebhard:
The Molecular Biology of Poliovirus - Taschenbuch

2011, ISBN: 9783709174678

ID: 912911319

Springer Verlag, 2011. 1. Paperback. New. SKU: MM-27330941; EAN: 9783709174678, Springer Verlag, 2011

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Koch, Friedrich/ Koch, Gebhard:
The Molecular Biology of Poliovirus - Taschenbuch

2011, ISBN: 9783709174678

ID: 830158355

Springer Verlag, 2011. 1. Paperback. New. SKU: MM-26560940; EAN: 9783709174678, Springer Verlag, 2011

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EAN (ISBN-13): 9783709174678
ISBN (ISBN-10): 3709174678
Taschenbuch
Erscheinungsjahr: 2011
Herausgeber: Springer Vienna

Buch in der Datenbank seit 10.10.2014 10:08:09
Buch zuletzt gefunden am 08.03.2017 14:23:46
ISBN/EAN: 9783709174678

ISBN - alternative Schreibweisen:
3-7091-7467-8, 978-3-7091-7467-8


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