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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - Stephan Beirer
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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - Taschenbuch

ISBN: 383251564X

Paperback, [EAN: 9783832515645], Logos Verlag Berlin, Logos Verlag Berlin, Book, [PU: Logos Verlag Berlin], Logos Verlag Berlin, The Jak/Stat1 signalling pathway is a prototypical example of a direct signal transduction system which relays external signals directly from the receptor located at the cellular membrane to its nuclear targetgenes. This work seeks to acquire a comprehensive theoretical understanding of the quantitative and qualitative aspects of Jak/Stat1 signal transduction, using a combination of different theoretical approaches and methods together with specific experimental measurements. This thesis consists of three independent parts. In partI the biological system is introduced and a detailed model of Jak/Stat1 signalling is presented. The estimation of the modelparameters is demonstrated. The model structure and the parameter values are verified using independent experimental measurements. Usingnumerical model simulations we investigate the dynamics of Stat1 signalling and examine the control properties of the systemprocesses. Part II of this thesis presents a general treatment of Jak/Stat signal transduction using analytical methods. We reduce thecomplexity of the detailed Jak/Stat model and obtain a simplified linear core model. Using this core model we derive a relation betweenthe lifetimes of the subcellular Stat fractions and their steady state concentrations. Furthermore we model general signal transductionsystems as networks of linear state transitions and derive a rule relating the distribution of control among the network processes withthe steady state occupancy of the specific network states. In the third part of this work the theoretical predictions of part I and IIabout the control properties of the subcellular transport processes of the Stat1 molecules are examined using experimental data fromdifferent Stat1 transport mutants. The changed phenotypes of these mutant proteins are compared to different model simulations. The highregulatory potential of the shuttling process of inactive Stat1 protein predicted by the model is confirmed., 1025612, Subjects, 349777011, Antiquarian, Rare & Collectable, 91, Art, Architecture & Photography, 51, Audio Cassettes, 267859, Audio CDs, 67, Biography, 68, Business, Finance & Law, 507848, Calendars, Diaries, Annuals & More, 69, Children's Books, 274081, Comics & Graphic Novels, 71, Computing & Internet, 72, Crime, Thrillers & Mystery, 637262, e-Books, 279254, Fantasy, 62, Fiction, 66, Food & Drink, 275835, Gay & Lesbian, 74, Health, Family & Lifestyle, 65, History, 64, Home & Garden, 63, Horror, 89, Humour, 275738, Languages, 61, Mind, Body & Spirit, 73, Music, Stage & Screen, 275389, Poetry, Drama & Criticism, 59, Reference, 58, Religion & Spirituality, 88, Romance, 57, Science & Nature, 279292, Science Fiction, 564334, Scientific, Technical & Medical, 60, Society, Politics & Philosophy, 55, Sports, Hobbies & Games, 13384091, Study Books, 83, Travel & Holiday, 266239, Books, 400530011, English, 400529011, Language (feature_browse-bin), 365481011, Refinements, 266239, Books, 492564011, Paperback, 492562011, Format (binding_browse-bin), 365481011, Refinements, 266239, Books, 182018031, Regular Size, 182016031, Font Size (format_browse-bin), 365481011, Refinements, 266239, Books

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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - Stephan Beirer
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Stephan Beirer:
Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - neues Buch

ISBN: 383251564X

Tapa blanda, [EAN: 9783832515645], Logos Verlag Berlin, Logos Verlag Berlin, Libro, [PU: Logos Verlag Berlin], Logos Verlag Berlin, The Jak/Stat1 signalling pathway is a prototypical example of a direct signal transduction system which relays external signals directly from the receptor located at the cellular membrane to its nuclear target genes. This work seeks to acquire a comprehensive theoretical understanding of the quantitative and qualitative aspects of Jak/Stat1 signal transduction, using a combination of different theoretical approaches and methods together with specific experimental measurements. This thesis consists of three independent parts. In part I the biological system is introduced and a detailed model of Jak/Stat1 signalling is presented. The estimation of the model parameters is demonstrated. The model structure and the parameter values are verified using independent experimental measurements. Using numerical model simulations we investigate the dynamics of Stat1 signalling and examine the control properties of the system processes. Part II of this thesis presents a general treatment of Jak/Stat signal transduction using analytical methods. We reduce the complexity of the detailed Jak/Stat model and obtain a simplified linear core model. Using this core model we derive a relation between the lifetimes of the subcellular Stat fractions and their steady state concentrations. Furthermore we model general signal transduction systems as networks of linear state transitions and derive a rule relating the distribution of control among the network processes with the steady state occupancy of the specific network states. In the third part of this work the theoretical predictions of part I and II about the control properties of the subcellular transport processes of the Stat1 molecules are examined using experimental data from different Stat1 transport mutants. The changed phenotypes of these mutant proteins are compared to different model simulations. The high regulatory potential of the shuttling process of inactive Stat1 protein predi, 599365031, Categorías, 902675031, Acción y aventura, 902486031, Arte, cine y fotografía, 902498031, Biografías, diarios y hechos reales, 902502031, Calendarios y agendas, 902503031, Ciencias, tecnología y medicina, 902517031, Consulta, 902516031, Cómics y manga, 902520031, Deporte, 902590031, Derecho, 902595031, Economía y empresa, 1349107031, Fantasía, terror y ciencia ficción, 902681031, Ficción erótica, 902682031, Ficción histórica, 902599031, Guías de estudio y repaso, 902600031, Historia, 902610031, Hogar, manualidades y estilos de vida, 902620031, Humor, 902621031, Infantil y juvenil, 902652031, Informática, internet y medios digitales, 902665031, Lengua, lingüística y redacción, 902673031, Libros de texto, 902674031, Literatura y ficción, 902685031, Policíaca, negra y suspense, 902693031, Política, 902702031, Religión, 902686031, Romántica, 902716031, Salud, familia y desarrollo personal, 902721031, Sociedad y ciencias sociales, 902729031, Viajes, 599364031, Libros

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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - Stephan Beirer
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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - gebrauchtes Buch

2007, ISBN: 383251564X

ID: 1536632424

[EAN: 9783832515645], [PU: Logos Verlag Berlin 2007-05-15], STAT1 SIGNALTRANSDUKTION MODELLIERUNG KONTROLLE KONTROLLKOEFFIZIENTEN, The Jak/Stat1 signalling pathway is a prototypical example of a direct signal transduction system which relays external signals directly from the receptor located at the cellular membrane to its nuclear targetgenes. This work seeks to acquire a comprehensive theoretical understanding of the quantitative and qualitative aspects of Jak/Stat1 signal transduction, using a combination of different theoretical approaches and methods together with specific experimental measurements. This thesis consists of three independent parts. In partI the biological system is introduced and a detailed model of Jak/Stat1 signalling is presented. The estimation of the modelparameters is demonstrated. The model structure and the parameter values are verified using independent experimental measurements. Usingnumerical model simulations we investigate the dynamics of Stat1 signalling and examine the control properties of the systemprocesses. Part II of this thesis presents a general treatment of Jak/Stat signal transduction using analytical methods. We reduce thecomplexity of the detailed Jak/Stat model and obtain a simplified linear core model. Using this core model we derive a relation betweenthe lifetimes of the subcellular Stat fractions and their steady state concentrations. Furthermore we model general signal transductionsystems as networks of linear state transitions and derive a rule relating the distribution of control among the network processes withthe steady state occupancy of the specific network states. In the third part of this work the theoretical predictions of part I and IIabout the control properties of the subcellular transport processes of the Stat1 molecules are examined using experimental data fromdifferent Stat1 transport mutants. The changed phenotypes of these mutant proteins are compared to different model simulations. The highregulatory potential of the shuttling process of inactive Stat1 protein predicted by the model is confirmed.

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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway - Stephan Beirer
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Mathematical Modelling of the Jak /Stat1 Signal Transduction Pathway Mathematical-Modelling-of-the-Jak-Stat1-Signal-Transduction-Pathway~~Stephan-Beirer Science>Mathematics>Mathematics Paperback, Logos Verlag

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