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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Shaistha Zaheeruddin
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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Taschenbuch

ISBN: 3838379845

Paperback, [EAN: 9783838379845], LAP LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing, Book, [PU: LAP LAMBERT Academic Publishing], LAP LAMBERT Academic Publishing, Oxidative stress (OS) is associated with many chronic states including cancer. Curcumin, a bioactive chemical of turmeric has potent antioxidant effects. We utilized metabolomics to evaluate signatures of OS in BOP (N-nitrosobis-2-(oxopropyl) amine) induced hamsters and their effect by curcumin. 32 hamsters were randomized into treatment (n=20; OS induced by BOP) and control (n=12) groups. After 12 weeks each group was subdivided by no (T0, C0) or 2% curcumin (T2, C2) diet. Proton nuclear magnetic resonance spectroscopy was conducted on urine and analyzed using Principal Component Analysis PCA;SIMCA P+, Umetrics. The PCA score plots showed clear separation between spectra from treatment (T0) and control (C0) groups, and curcumin fed (T2) groups (p<0.05). Partial Least Square (PLS) analysis correlated the metabolomic profiles with Total Antioxidant, cyclooxygenase-2 and NF-kB activity well. Metabolites responsible for the inter-group differences were linked to the pyrimidine, purine and glycine, serine and threonine pathways. With further investigation these metabolites, in addition to providing a mechanistic insight, may serve as potential signatures of OS., 14116, Diseases, 14117, AIDS & HIV, 14125, Brain, 227212, Cancer, 14131, Cardiovascular, 227207, Communicable Diseases, 282810, Diabetes, 14145, Digestive Organs, 14149, Extremities, 14166, Psoriasis, 14170, Viral, 227692, Pathology, 227203, Internal Medicine, 265542, Medicine, 173514, Medical Books, 1000, Subjects, 283155, Books

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Effect of Curcumin on BOP Induced Oxidative Stress in a Hams - Shaistha Zaheeruddin
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2010, ISBN: 9783838379845

[ED: Pappeinband], [PU: Lap Lambert Acad. Publ.], - Oxidative stress (OS) is associated with many chronic states including cancer. Curcumin, a bioactive chemical of turmeric has potent antioxidant effects. We utilized metabolomics to evaluate signatures of OS in BOP (N-nitrosobis-2-(oxopropyl) amine) induced hamsters and their effect by curcumin. 32 hamsters were randomized into treatment (n=20 OS induced by BOP) and control (n=12) groups. After 12 weeks each group was subdivided by no (T0, C0) or 2% curcumin (T2, C2) diet. Proton nuclear magnetic resonance spectroscopy was conducted on urine and analyzed using Principal Component Analysis PCASIMCA P+, Umetrics. The PCA score plots showed clear separation between spectra from treatment (T0) and control (C0) groups, and curcumin fed (T2) groups (p0.05). Partial Least Square (PLS) analysis correlated the metabolomic profiles with Total Antioxidant, cyclooxygenase-2 and NF-kB activity well. Metabolites responsible for the inter-group differences were linked to the pyrimidine, purine and glycine, serine and threonine pathways. With further investigation these metabolites, in addition to providing a mechanistic insight, may serve as potential signatures of OS. - Besorgungstitel - vorauss. Lieferzeit 3-5 Tage.., [SC: 0.00]

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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Shaistha Zaheeruddin
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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Taschenbuch

2010, ISBN: 3838379845

Paperback, [EAN: 9783838379845], LAP LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing, Book, [PU: LAP LAMBERT Academic Publishing], 2010-12-01, LAP LAMBERT Academic Publishing, 270847, Diseases & Disorders, 270852, Immunology, 270855, Infectious & Contagious Diseases, 270860, Oncology, 270842, Internal Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 922610, Diseases & Disorders, 922820, Infectious & Contagious Diseases, 922828, Mental Diseases & Disorders, 922816, Radiology, 922532, Medicine, 57, Science & Nature, 1025612, Subjects, 266239, Books, 571334, Diseases & Disorders, 571382, Medical Sciences A-Z, 564356, Medicine & Nursing, 564334, Scientific, Technical & Medical, 1025612, Subjects, 266239, Books

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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model
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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model - Taschenbuch

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Effect Of Curcumin On Bop Induced Oxidative Stress In A Hamster Model - Shaistha Zaheeruddin
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Shaistha Zaheeruddin, Paperback, English-language edition, Pub by LAP Lambert Academic Publishing Textbooks New, Books~~Medicine~~Diseases, Effect-of-Curcumin-on-BOP-Induced-Oxidative-Stress-in-a-Hamster-Model~~Shaistha-Zaheeruddin, 999999999, Effect Of Curcumin On Bop Induced Oxidative Stress In A Hamster Model, Shaistha Zaheeruddin, 3838379845, LAP Lambert Academic Publishing, , , , , LAP Lambert Academic Publishing

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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model

Oxidative stress (OS) is associated with many chronic states including cancer. Curcumin, a bioactive chemical of turmeric has potent antioxidant effects. We utilized metabolomics to evaluate signatures of OS in BOP (N-nitrosobis-2-(oxopropyl) amine) induced hamsters and their effect by curcumin. 32 hamsters were randomized into treatment (n=20; OS induced by BOP) and control (n=12) groups. After 12 weeks each group was subdivided by no (T0, C0) or 2% curcumin (T2, C2) diet. Proton nuclear magnetic resonance spectroscopy was conducted on urine and analyzed using Principal Component Analysis PCA;SIMCA P+, Umetrics. The PCA score plots showed clear separation between spectra from treatment (T0) and control (C0) groups, and curcumin fed (T2) groups (p0.05). Partial Least Square (PLS) analysis correlated the metabolomic profiles with Total Antioxidant, cyclooxygenase-2 and NF-kB activity well. Metabolites responsible for the inter-group differences were linked to the pyrimidine, purine and glycine, serine and threonine pathways. With further investigation these metabolites, in addition to providing a mechanistic insight, may serve as potential signatures of OS.

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EAN (ISBN-13): 9783838379845
ISBN (ISBN-10): 3838379845
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: LAP Lambert Acad. Publ.
104 Seiten
Gewicht: 0,171 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 01.06.2011 02:26:54
Buch zuletzt gefunden am 11.06.2017 21:52:59
ISBN/EAN: 9783838379845

ISBN - alternative Schreibweisen:
3-8383-7984-5, 978-3-8383-7984-5


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