Modern Methods in Crop Protection Research - Erstausgabe

EAN (ISBN-13): 9783527331758
ISBN (ISBN-10): 3527331751
Gebundene Ausgabe
Erscheinungsjahr: 2012
Herausgeber: Wiley-VCH
420 Seiten
Gewicht: 0,990 kg
Sprache: Englisch

Buch in der Datenbank seit 2009-11-18T09:30:18+01:00 (Berlin)
Detailseite zuletzt geändert am 2023-08-04T14:23:30+02:00 (Berlin)
ISBN/EAN: 9783527331758

ISBN - alternative Schreibweisen:
3-527-33175-1, 978-3-527-33175-8
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: witschel, peter krämer, wolfgang jeschke, ulrich kramer, burscheid, schirm, schirmer matthias, peter matt, matthia ulrich, jesch, kraemer, wiley vch, krämer wolfgang stilblüten
Titel des Buches: cro, modern

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Daten vom Verlag:

Autor/in: Peter Jeschke; Wolfgang Krämer; Ulrich Schirmer; Matthias Witschel
Titel: Modern Methods in Crop Protection Research
Verlag: Wiley-VCH; Wiley-VCH
420 Seiten
Erscheinungsjahr: 2012-10-15
Gedruckt / Hergestellt in Singapur.
Gewicht: 0,992 kg
Sprache: Englisch
185,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 29mm

BB; Hardcover, Softcover / Chemie; Agrochemie; Verstehen; Chemie; Agrochemicals; Agrochemikalie; Agrochemikalien; Biowissenschaften; Botanik / Zellbiologie; Chemie; Chemistry; Life Sciences; Natural Products; Naturstoff; Naturstoffchemie; Pflanzenschutzmittel; Plant Cell Biology; Agrochemikalien; Naturstoffchemie; Botanik / Zellbiologie

PREFACE PART I: Methods for the Design and Optimization of New Active Ingredients HIGH-THROUGHPUT SCREENING IN AGROCHEMICAL RESEARCH Introduction Target-Based High-Throughput Screening Other Screening Approaches In Vivo High-Throughput Screening Conclusions COMPUTATIONAL APPROACHES IN AGRICULTURAL RESEARCH Introduction Research Strategies Ligand-Based Approaches Structure-Based Approaches Estimation of Adverse Effects In-Silico Toxicology Programs and Databases Conclusion QUANTUM CHEMICAL METHODS IN THE DESIGN OF AGROCHEMICALS Introduction Computational Quantum Chemistry: Basics, Challenges, and New Developments Minimum Energy Structures and Potential Energy Surfaces Physico-Chemical Properties Quantitative Structure-Activity Relationships Outlook THE UNIQUE ROLE OF HALOGEN SUBSTITUENTS IN THE DESIGN OF MODERN CROP PROTECTION COMPOUNDS Introduction The Halogen Substituent Effect Insecticides and Acaricides Containing Halogens Fungicides Containing Halogens Plant Growth Regulators (PGRs) Containing Halogens Herbicides Containing Halogens Summary and Outlook PART II: New Methods to Identify the Mode of Action of Active Ingredients RNA INTERFERENCE (RNAI) FOR FUNCTIONAL GENOMICS STUDIES AND AS A TOOL FOR CROP PROTECTION Introduction RNA Silencing Pathways RNAi as a Tool for Functional Genomics in Plants RNAi as a Tool for Engineering Resistance against Fungi and Oomycetes RNAi as a Tool for Engineering Insect Resistance RNAi as a Tool for Engineering Nematodes Resistance RNAi as a Tool for Engineering Virus Resistance RNAi as a Tool for Engineering Bacteria Resistance RNAi as a Tool for Engineering Parasitic Weed Resistance RNAi Safety in Crop Plants Summary and Outlook FAST IDENTIFICATION OF THE MODE OF ACTION OF HERBICIDES BY DNA CHIPS Introduction Gene Expression Profiling: A Method to Measure Changes of the Complete Transcriptome Classification of the Mode of Action of an Herbicide Identification of Prodrugs by Gene Expression Profiling Analyzing the Affected Metabolic Pathways Gene Expression Profiling: Part of a Toolbox for Mode of Action Determination MODERN APPROACHES FOR ELUCIDATING THE MODE OF ACTION OF NEUROMUSCULAR INSECTICIDES Introduction Biochemical and Electrophysiological Approaches Fluorescence-Based Approaches for Mode of Action Elucidation Genomic Approaches for Target Site Elucidation Conclusion NEW TARGETS FOR FUNGICIDES Introduction: Current Fungicide Targets A Retrospective Look at the Discovery of Targets for Fungicides New Sources for New Fungicide Targets in the Future? Methods to Identify a Novel Target for a Given Compound Methods of Identifying Novel Targets without Pre-Existing Inhibitors Non-Protein Targets Resistance Inducers Beneficial Side Effects of Commercial Fungicides Concluding Remarks PART III: New Methods to Improve the Bioavailability of Active Ingredients NEW FORMULATION DEVELOPMENTS Introduction Drivers for Formulation Type Decisions Description of Formulation Types, Their Properties, and Problems during Development Bioavailability Optimization Conclusions and Outlook POLYMORPHISM AND THE ORGANIC SOLID STATE: INFLUENCE ON THE OPTIMIZATION OF AGROCHEMICALS Introduction Theoretical Principles of Polymorphism Analytical Characterization of Polymorphs Patentability of Polymorphs Summary and Outlook THE DETERMINATION OF ABRAHAM DESCRIPTORS AND THEIR APPLICATION TO CROP PROTECTION RESEARCH Introduction Definition of Abraham Descriptors Determination of Abraham Descriptors: General Approach Determination of Abraham Descriptors: Physical Properties Determination of Abraham Descriptors: Examples Application of Abraham Descriptors: Descriptor Profiles Application of Abraham Descriptors: LFER Analysis Application of Abraham Descriptors: Generality of Approach PART IV: Modern Methods for Risk Assessment ECOLOGICAL MODELING IN PESTICIDE RISK ASSESSMENT: CHANCES AND CHALLENGES Introduction Ecological Models in the Regulatory Environment An Overview of Model Approaches Regulatory Challenges THE USE OF METABOLOMICS IN VIVO FOR THE DEVELOPMENT OF AGROCHEMICAL PRODUCTS Introduction to Metabolomics MetaMap¿Tox Data Base Evaluation of Metabolome Data Use of Metabolome Data for Development of Agrochemicals Discussion Concluding Remarks SAFETY EVALUATION OF NEW PESTICIDE ACTIVE INGREDIENTS: ENQUIRY-LED APPROACH TO DATA GENERATION Background What Is the Purpose of Mammalian Toxicity Studies? Addressing the Knowledge Needs of Risk Assessors Opportunities for Generating Data of Direct Relevance to Human Health Risk Assessment within the Existing Testing Paradigm Enquiry-Led Data Generation Strategies Conclusions ENDOCRINE DISRUPTION: DEFINITION AND SCREENING ASPECTS IN THE LIGHT OF THE EUROPEAN CROP PROTECTION LAW Introduction Endocrine Disruption: Definitions Current Regulatory Situation in the EU US EPA Endocrine Disruptor Screening Program and OECD Conceptual Framework for the Testing and Assessment of Endocrine-Disrupting Chemicals ECETOC Approach Methods to Assess Endocrine Modes of Action and Endocrine-Related Adverse Effects in Screening and Regulatory Contexts Proposal for Decision Criteria for EDCs: Regulatory Agencies INDEX