ISBN: 9783642654466

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergo… Mehr…

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve changes in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune population of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRANCIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hemagglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism. New Textbooks>Trade Paperback>Medicine>Medical Ref>Med Ref, Springer Berlin Heidelberg Core >1 >T<

ISBN: 9783642654466

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergo… Mehr…

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve changes in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune population of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRANCIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hemagglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism. New Textbooks>Trade Paperback>Medicine>Medical Ref>Med Ref, Springer Berlin Heidelberg Core >1 >T<

2011, ISBN: 3642654460

Softcover reprint of the original 1st ed. 1972 Kartoniert / Broschiert Medizin, allgemein, Biowissenschaften, allgemein, Antigen; Immunität; Biology; diseases; growth; peptides; virus, … Mehr…

Softcover reprint of the original 1st ed. 1972 Kartoniert / Broschiert Medizin, allgemein, Biowissenschaften, allgemein, Antigen; Immunität; Biology; diseases; growth; peptides; virus, mit Schutzumschlag 11, [PU:Springer Berlin Heidelberg; Springer-Verlag GmbH]<

2011, ISBN: 3642654460

Softcover reprint of the original 1st ed. 1972 Kartoniert / Broschiert Medizin, allgemein, Biowissenschaften, allgemein, Antigen; Immunität; Biology; diseases; growth; peptides; virus, … Mehr…

Softcover reprint of the original 1st ed. 1972 Kartoniert / Broschiert Medizin, allgemein, Biowissenschaften, allgemein, Antigen; Immunität; Biology; diseases; growth; peptides; virus, mit Schutzumschlag 11, [PU:Springer Berlin Heidelberg; Springer Berlin]<

ISBN: 9783642654466

Springer , pp. 244 . Papeback. New., Springer, 6